NTRC Publications:

  • Grobben et al. (2021) Targeting indoleamine 2,3-dioxygenase in cancer models using the novel small molecule inhibitor NTRC 3883-0, Frontiers in Immunology, section Cancer Immunity and Immunotherapy, online first, January 28, 2021. (collaboration with Radboud University Medical Center)
    https://www.frontiersin.org/articles/10.3389/fimmu.2020.609490/full
  • Conlon et al. (2021) Comparative analysis of drug response and gene profiling of the HER2-targeted tyrosine kinase inhibitors, British Journal of Cancer, online first, January 21, 2021. (collaboration with Dublin City University and Puma Biotechnology, Inc.)
    https://www.nature.com/articles/s41416-020-01257-x.
  • den Ouden et al. (2020) Chemotherapy sensitivity testing on ovarian cancer cells isolated from malignant ascites, Oncotarget, 11:4570-4581. (collaboration with Radboud University Medical Center)
    https://www.oncotarget.com/article/27827/
  • Grobben et al. (2020) Structural insights into human Arginase-1 pH dependence and its inhibition by the small molecule inhibitor CB-1158. Journal of Structural Biology: X, 4:100014.
    https://doi.org/10.1016/j.yjsbx.2019.100014
  • Libouban et al. (2017) Stable aneuploid tumors cells are more sensitive to TTK inhibition than chromosomally unstable cell lines, Oncotarget, 8 (24):38309–38325. (collaboration with Netherlands Cancer Institute)
    https://doi.org/10.18632/oncotarget.16213

References to the assay technologies Arginase Goldand NFK Green:

  • More information on the assay technologies Arginase Goldand NFK Green can be found at www.residencetimer.com

References to NTRC Science Platforms:

  • van der Zwet et al. (2020) The central role of MAPK-ERK signalling in IL7-dependent and IL7-independent steroid resistance reveals a broad application of MEK-inhibitors compared to JAK1/2-inhibition in T-ALL, Oral presentation, ASH Annual Meeting 2020 (Affiliation: Prinses Máxima Center for Pediatric Oncology)
  • Cordo et al. (2020) Phospho-proteomic profiling of T-Cell Acute Lymphoblastic Leukemia identifies targetable kinase activities and novel treatment combination strategies, Oral presentation, ASH Annual Meeting 2020 (Affiliation: Prinses Máxima Center for Pediatric Oncology)
  • Borsari et al. (2019) Preclinical Development of PQR514, a Highly Potent PI3K Inhibitor Bearing a Difluoromethyl−Pyrimidine Moiety, ACS Medicinal Chemistry Letters, 10:1473-1479. (Affilitations: University of Basel, PIQUR Therapeutics AG)
    https://pubs.acs.org/doi/full/10.1021/acsmedchemlett.9b00333
  • Rageot et al. (2019) (S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor of Class I PI3K and mTOR Kinase, Journal of Medicinal Chemistry, 62 (13):6241-6261. (Affiliations: University of Basel, PIQUR Therapeutics AG)
    https://doi.org/10.1021/acs.jmedchem.9b00525
  • Grünewald et al. (2019) Rogaratinib: A potent and selective pan‐FGFR inhibitor with broad antitumor activity in FGFR‐overexpressing preclinical cancer models, International Journal of Cancer, 145 (5): 346-1357. (Affiliation: Bayer AG)
    https://doi.org/10.1002/ijc.32224
  • Gentile et al. (2018) A Novel Interaction Between the TLR7 and a Colchicine Derivative Revealed Through a Computational and Experimental Study, Pharmaceuticals, 11 (1):22. (Affiliation: University of Alberta)
    https://doi.org/10.3390/ph11010022
  • Bohnacker et al. (2017) Deconvolution of Buparlisib’s mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention, Nature Communications, 8:14683. (Affiliation: University of Basel)
    https://www.nature.com/articles/ncomms14683
  • Wentsch et al. (2017) Optimized Target Residence Time: Type 1½Inhibitors for p38a MAP Kinase with Improved Binding Kinetics through Direct Interaction with the R-Spine, Angewandte Chemie International Edition, 56 (19):5363-5367. (Affiliation: Universität Tübingen)
    https://doi.org/10.1002/anie.201701185
  • Canté-Barrett et al. (2016) MEK and PI3K-AKT inhibitors synergistically block activated IL7 receptor signaling in T-cell acute lymphoblastic leukemia, Leukemia, 30:1832-1843. (Affiliations: Erasmus MC, NTRC)
    https://www.nature.com/articles/leu201683
  • Maia et al. (2015) Inhibition of the spindle assembly checkpoint kinase TTK enhances the efficacy of docetaxel in a triple-negative breast cancer model, Annals of Oncology, 26 (10):2180-2192. (Affiliations: Netherlands Cancer Institute, NTRC)
    https://doi.org/10.1093/annonc/mdv293
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